Regenerative Cell Treatment

Our bodies are created to be self-healing and self-regulating. Outside influences such as age, injury, and environmental factors seriously diminish our ability to heal and often times speed up neurodegeneration. Regenerative Cell Therapy may be the right choice for you, aiding in cultivating an optimal healing environment within the body.

Supplementing what already exists within the body is what makes birthing tissue the idea source for regenerative products. Specifically, the Wharton’s Jelly layer of the umbilical cord. Wharton’s jelly stem cells are what we offer at Revive Treatment Centers.


What Is Wharton’s Jelly?

Wharton’s jelly is a gelatinous substance found in the umbilical cord that provides cushioning and support to the umbilical vein and arteries. Wharton’s jelly contains stem cell genes that can be extracted and cultured to make more stem cells and differentiated cells. Extracted cells from Wharton’s jelly are used to make various adult cells, including neural cells. Wharton’s jelly mostly contains:

  • Mucopolysaccharides: compounds that make up connective tissue
  • Fibroblasts: cells that make up the structural framework for connective tissue in humans
  • Macrophages: cells that protect the body from harmful foreign particles

The primary role of Wharton’s jelly is to protect umbilical cord blood vessels.

After the birth of a child, Wharton’s jelly also acts as a physiological clamp on the umbilical cord. When the baby is born, the structure of Wharton’s jelly changes as a result of the change in temperature. The change in structure acts like a clamping action on the umbilical cord, slowing the flow of blood. This clamping action usually occurs approximately 5 minutes after the birth of the child.

Wharton’s jelly contains stem cell genes that can be extracted and cultured to make more stem cells and differentiated cells. Scientists have already managed to extract cells from Wharton’s jelly and use them to make various adult cells, including neural cells (Mitchell et al., 2003). The cells created from Wharton’s jelly may be very useful in the treatment of many diseases and illnesses.

 

How Are Regenerative Cells Collected?

Comprehensive medical and social histories of the donor are obtained, and tissues are procured, processed, and tested in accordance with standards established by FDA requirements to minimize potential risks of disease transmission to recipients.  The cells for Revive’s Regenerative Cell Treatment are collected from mothers who have donated their placental tissue after a healthy full-term birth– no babies are harmed. Minimally manipulated tissue products are prepared to utilize proprietary extraction methods that reduce the loss of important structural proteins, cytokines and growth factors.

Our Regenerative Cell Treatment is a revolutionary breakthrough treatment option for people suffering from inflammation, reduced mobility, sports injuries, tissue and ligament damage, or chronic pain. Regenerative Cell Therapy is an injectable regenerative tissue matrix solution, that oftentimes leaves the patient feeling relief after only ONE treatment. This cutting-edge treatment takes the best components from all the current non-invasive treatment options and puts them into one.

Stem Cells are the basis for human development. Regenerative Cell Treatment can stimulate your body’s own stem cells to proliferate and target damaged cells and repair them. Through neurological Regenerative Cell Treatment, it is possible to repair damaged areas of the brain, restore function, and prevent further neurodegeneration.

Regenerative Medicine is now one of the easiest, minimally invasive methods to improve your quality of life. Stem cells play a critical part in regenerative medicine. Once stem cells are deployed, they act by first coming to the sites of injury.  They release growth factors which help in controlling the inflammatory response that, in turn, heals damaged or degenerative tissue. In addition, they have the ability to increase blood flow to an area by forming new vascular tissue. This process leads to increased blood flow and necessary nutrients to the injured areas which aid in the healing process.

Regenerative Cell Treatment
has been researched to provide lubrication, reduce inflammation, facilitate mobility, and to protect & cushion the affected joints.

A distinct advantage of human Wharton’s jelly-derived stem cells over bone marrow-derived stem cells is the ease with which they are isolated. Not only is it technically relatively simple to retrieve stem cells from the umbilical cord, but it is less invasive than doing so from the bone marrow.

In current studies, researchers characterized the best way to isolate the mesenchymal stem cells from the Wharton’s jelly and also compared the stem cells that come from Wharton’s jelly to those that come from the bone marrow. According to their analysis, some of the critical advantages of mesenchymal stem cells deriving from Wharton’s jelly rather than from bone marrow are the relative abundance of genes associated with immune system functioning, cell adhesion, and proliferation. Each of these functions is important for stem cell therapeutic applications, and so having more genes that support these functions is beneficial.

Other advantages of Wharton’s jelly-derived mesenchymal stem cells are that collecting them does not raise ethical concerns and that the cells themselves proliferate rapidly. In the past, some stem cells have had a tendency to lead to tumors and were prone to cause immune reactions. New research suggests that utilizing Wharton’s jelly-derived stem cells appears to circumvent both of these problems, making them valuable for a variety of applications in medicine.

 

Benefits of Regenerative Medicine:

  • Reduce Pain & Inflammation
  • Natural healing properties
  • Increase blood flow
  • Minimally invasive
  • Outpatient treatment
  • Highly effective & affordable
  • NO downtime
  • Safe and precise to degenerative area
  • Promotes Soft tissue Growth
  • No adverse reaction

Q & A

What is Wharton’s Jelly?
Wharton’s jelly is a gelatinous substance in the umbilical cord that provides cushioning and support to the umbilical vein and arteries. The cushioning and protective elements from Wharton’s jelly consists of a network of structural biomolecules, pericytes, mesenchymal stem cells, cytokines, chemokines and growth factors.

What is cryopreservation?
Cryopreservation is the process of freezing biological material at extreme temperatures; most common -196 °C/-321 °F in liquid nitrogen (N2). At these low temperatures, all biological activity stops, including the biochemical reactions that lead to cell death and DNA degradation. This preservation method, in theory, makes it possible to store living cells as well as other biological material unchanged for centuries.

How can umbilical cord stem cells be used in treatments today?
Umbilical cord stem cells can be used therapeutically to help restore function to the immune system and blood-producing systems, e.g. when these cells have been damaged by chemotherapy or radiotherapy.

What makes cord blood cells different?
Cord blood stem cells are biologically younger and are more flexible compared to adult stem cells from other sources like bone marrow.

Where do Predictive’s products come from?
Predictive’s human cell and tissue materials come from the umbilical cords of healthy, full-term deliveries. These products do not contain any fetal or embryonic tissue.

Are Predictive’s products safe?
Our products are rigorously tested to FDA guidelines in our CLIA certified lab. Thousands of patients have used Predictive’s tissue allografts with no adverse effects.

How long does a procedure with Predictive products take?
Depending upon the area being treated, the procedure can be completed in a single office visit. Your doctor will be able to provide details specific to your treatment plan.

Does the procedure hurt?
The use of these products does not require any invasive procedures, resulting in less pain and a shorter procedure time.

When will I feel the benefits?
Depending upon the severity of the injury and your personal health, recovery time can vary. Your physician can provide more information.

 

 

Research into Umbilical Cord Wharton’s Jelly Stem Cells

A research paper published in 2015 highlights the value of Wharton jelly as a source of mesenchymal stem cells (Watson et al., 2015). The paper indicates that cryopreservation of both the umbilical cord blood and Wharton’s jelly may be worthwhile, to access many new forms of treatment.

The MSCs generated by Wharton’s jelly are particularly useful because they are in an early embryologic phase, which makes them more adaptable for differentiation and transplantation.

Mesenchymal stem cells are multipotent stem cells that can differentiate into a number of other cell types including —

  • Chondrocytes (cartilage cells)
  • Osteoblasts (bone cells)
  • Myocytes (muscle cells)
  • Adipocytes (fat cells)
  • Hepatocytes (liver cells)
  • Neurones (brain cells) and
  • Cardiomyocytes (heart cells).

MSCs also have the capacity to migrate to sites of inflammation and exert anti-inflammatory and immunosuppressive capabilities (Kim & Cho, 2013).

MSCs are the focus of many clinical trials and are thought to be particularly useful in a field of research known as regenerative medicine. Regenerative medicine seeks to develop treatments that replace or regenerate human cells, tissues or organs to restore or establish normal function. Stem cells that are capable of generating new cells are particularly useful for regenerating cells and tissue.

 

Some of the recent discoveries made using Wharton’s jelly stem cells include:

  • Adult Mesenchymal Stem Cells Safe and Effective in Acute Myocardial Infarction
  • Researchers found that Wharton’s Jelly-derived mesenchymal stem cells are a safe and effective treatment for acute myocardial infarction (heart attacks) (PrNewswire, 2015)
  • Human Wharton’s jelly mesenchymal stem cells promote skin wound healing
  • Researchers found that WJ-MSCs increased normal skin fibroblast proliferation and migration, promoting wound healing (Arno et al., 2014)
  • Scientists grow artificial skin using umbilical cord stem cells
  • Spanish scientists, from the Tissue Engineering Research Group, from the Dept. of Histology at the University of Granada managed to grow artificial skin from WJ-MSCs  (Stemcelldigest.com, 2013)
  • Scientists have found that WJ-MSCs can improve recovery in brain-damaged mice
  • Scientists have already used Wharton Jelly-derived Mesenchymal Stromal Cells to treat brain damage in mice effectively (Cheng et al., 2015).
  • Breakthroughs are occurring at a rapid pace and WJ-MSCs have a great deal of potential.

Sources

Arno, A., Amini-Nik, S., Blit, P., Al-Shehab, M., Belo, C., & Herer, E. et al. (2014). Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling. Stem Cell Research & Therapy, 5(1), 28. http://dx.doi.org/10.1186/scrt417

Cheng, T., Yang, B., Li, D., Ma, S., Tian, Y., & Qu, R. et al. (2015). Wharton’s Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain Injury. Cellular And Molecular Neurobiology, 35(5), 641-649. http://dx.doi.org/10.1007/s10571-015-0159-9

Dasari, V. (2014). Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World Journal Of Stem Cells, 6(2), 120.http://dx.doi.org/10.4252/wjsc.v6.i2.120

Dazzi, F., & Horwood, N. (2015). Potential of mesenchymal stem cell therapy.  – PubMed – NCBI. Ncbi.nlm.nih.gov. Retrieved 19 October 2015, from http://www.ncbi.nlm.nih.gov/pubmed/17906466

Kim, N., & Cho, S. (2013). Clinical applications of mesenchymal stem cells. Korean J Intern Med, 28(4), 387.http://dx.doi.org/10.3904/kjim.2013.28.4.387

Mitchell, K., Weiss, M., Mitchell, B., Martin, P., Davis, D., & Morales, L. et al. (2003). Matrix Cells from Wharton’s Jelly Form Neurons and Glia. STEM CELLS, 21(1), 50-60. http://dx.doi.org/10.1634/stemcells.21-1-50

PrNewswire,. (2015). Beike Biotechnology Publishes New Research Finding Adult Mesenchymal Stem Cells Safe and Effective in Acute Myocardial Infarction. Prnewswire.com. Retrieved 16 November 2015, from http://www.prnewswire.com/news-releases/beike-biotechnology-publishes-new-research-finding-adult-mesenchymal-stem-cells-safe-and-effective-in-acute-myocardial-infarction-300116154.html

Ramsden, C., Powner, M., Carr, A., Smart, M., da Cruz, L., & Coffey, P. (2013). Stem cells in retinal regeneration: past, present and future. Development, 140(12), 2576-2585. http://dx.doi.org/10.1242/dev.092270

Stemcelldigest.com,. (2013). Scientists grow artificial skin using stem cells from the umbilical cord | Stem Cell News Digest. Stemcellnewsdigest.com. Retrieved 16 November 2015, from http://www.stemcellnewsdigest.com/medical-news-2/scientists-grow-artificial-skin-using-stem-cells-from-the-umbilical-cord/

Tanna, T., & Sachan, V. (2015). Mesenchymal stem cells: potential in treatment of neurodegenerative diseases.  – PubMed – NCBI. Ncbi.nlm.nih.gov. Retrieved 19 October 2015, from http://www.ncbi.nlm.nih.gov/pubmed/25248677

Volarevic, V., Nurkovic, J., Arsenijevic, N., & Stojkovic, M. (2014). Concise Review: Therapeutic Potential of Mesenchymal Stem Cells for the Treatment of Acute Liver Failure and Cirrhosis. STEM CELLS, 32(11), 2818-2823. http://dx.doi.org/10.1002/stem.1818

Verter, D. (2015). Parent’s Guide to Cord Blood. Parentsguidecordblood.org. Retrieved 26 October 2015, fromhttp://parentsguidecordblood.org/diseases.php#standard

Watson, N., Divers, R., Kedar, R., Mehindru, A., Mehindru, A., Borlongan, M., & Borlongan, C. (2015). Discarded Wharton jelly of the human umbilical cord: a viable source for mesenchymal stromal cells. Cytotherapy, 17(1), 18-24.http://dx.doi.org/10.1016/j.jcyt.2014.08.009